This research aims to explore the intricate relationships between human factors affecting information security, the sense of security, occupational health and safety for social workers, and the professional and occupational well-being of social workers. Furthermore, this research has used sense of security as a mediating variable among the proposed direct path of this research. In response to the evolving landscape of information technology and its impact on social work practice, the study seeks to contribute empirical insights that inform organizational policies, educational frameworks, and support structures. This research employed the STATA-SEM approach for advanced statistical analysis. Moreover, the data was collected from 199 social workers, working in the Kingdom of Saudi Arabia. The study validates measurement instruments adapted from prior research and utilizes Direct Path and Mediating Path Analyses to explore the proposed direct and mediated impacts. The empirical findings reveal significant direct influences of human factors on professional security and safety, occupational health and safety, and the sense of security. The study also reveals the critical mediating role of sense of security, elucidating its impact on broader dimensions of social work practitioners' well-being. This research contributes novel insights by blending quantitative rigor with nuanced exploration, enriching our theoretical understanding of information security challenges in social work. The findings hold significance for policymakers, organizational leaders, and educators, offering practical strategies to foster a secure and supportive work environment for social work professionals in the face of escalating information security demands.